Indomethacin from what these tablets. Indomethacin - instructions for use and reviews

Content

There are chronic ailments, the exacerbation of which brings severe suffering to patients due to sharp constant pain. To alleviate pain in such diseases, doctors recommend Indomethacin tablets, which bring a tangible effect, relieving pain, allowing a person to lead a relatively normal life without suffering. Indomethacin in tablets is considered a proven universal remedy that helps at different stages of diseases.

What is indomethacin tablets

As an anti-inflammatory, fever-reducing and anti-clotting drug, Indomethacin tablets are used to suppress inflammatory foci in the body, increase serous exudates and reduce tissue proliferation characteristic of inflammation of various etiologies. Being used to relieve rheumatic pain in the joints, the drug Indomethacin not only extinguishes sharp pain, but also helps to reduce the volume of edema and tumors. This action returns patients to the former quality of life.

However, it is not worth trying to treat a variety of ailments on your own using only these pills. Doctors prescribe the drug Indomethacin to patients as an adjuvant in the main treatment, which consists of drugs that have a selective effect on the cause of the disease. If you "suppress" the pain with Indomethacin tablets for a long period of time, without contacting a specialist, then there is a possibility of additional diseases, since the drug has an extensive list of side effects.

Compound

The medicine is available in the form of round light or dark yellow tablets, which include inclusions. If you cut the tablet in half, you can see that it has two layers. The main active ingredient is indomethacin itself. In addition to it, each tablet contains:

cellactose;
potato starch;
calcium or magnesium stearate;
titanium dioxide;
oidragite or eudrogit;
talc;
dibutyl phthalate;
diethyl phthalate;
colloidal silicon dioxide;
polyvinylpyrrolidone;
dye orange or brown.

Pharmacological action of Indomethacin tablets

The mechanism of action of Indomethacin is that the drug inhibits the activity of the apparatus of the enzymatic group that produces prostaglandin hormones, which are most actively involved in the initiation and development of an inflammatory focus in the joints or the body. Bone marrow production of platelets, which contribute to painful swelling and tumors, also decreases. At the same time, the temperature of the body area on which the state of inflammation has arisen decreases, the pain syndrome decreases, morning stiffness and swelling go away.

After taking, according to the description, the tablets are absorbed very quickly, starting to act after 20-30 minutes, the maximum concentration of Indomethacin in the bloodstream is reached after 2 hours. A pronounced anti-inflammatory effect occurs after 5-7 days of continuous use. Excreted by the kidneys or intestines after 6-8 hours, after intensive processing by the liver.

antibiotic or not

Many people mistakenly take Indomethacin for an antibacterial drug, trying to treat bacterial infections with pills. However, the drug belongs to the group of NSAIDs, it does not act on pathogens, but on inflammation itself, which is the body's response to exogenous factors. Do not take medicine as an antibiotic! By acting in this way, you can start the disease, and the treatment will continue in the hospital. It must be remembered that indomethacin tablets relieve the symptoms of the disease without affecting its cause.

Application

Indomethacin tablets are prescribed by doctors in the presence of the following pathologies in order to reduce acute pain:

rheumatoid arthritis;
polyarthritis of different genesis and etiology;
periarthritis (inflammation of the tissues around the joint);
ankylosing spondylitis (damage to the vertebral joints);
gout (joint damage associated with an excess of uric acid in the body);
thrombophlebitis;
various periarticular ailments - bursitis, tendonitis;
osteoarthritis;
relief of possible inflammation after surgery;
inflammation of the dental nerve;
in the complex therapy of ENT diseases.

Instructions for use of tablets Indomethacin

For adults, the initial dose corresponds to 2-3 tablets per day, divided into 2-3 doses, which must be swallowed without chewing and washed down with milk after meals. If this dose of Indomethacin is not enough to relieve pain, then the number of tablets taken is doubled, bringing it up to 6 pieces per day (2 tablets per dose). However, the maximum dose of Indomethacin should not exceed 200 mg per day. To achieve the desired effect, Indomethacin should be drunk regularly for at least 10 days.

Sometimes doctors recommend drinking Indomethacin for a long time, for a whole month, depending on the severity of inflammation and the intensity of pain. If, without good reason, without good reason, stop treatment with a medication without permission, then all the signs of the disease, according to patients, appear again, so you must strictly follow the recommendations of doctors and the instructions for use, which is attached to each package of tablets.

Indomethacin for children

Children under 14 years of age are an absolute contraindication not only for Indomethacin tablets, but also for gels, ointments, eye drops and rectal suppositories. If a small child found a package of pills and ate them, then you should immediately wash his stomach, provide first aid for poisoning and call an ambulance for emergency admission to the hospital.

Use in the elderly

The use of Indomethacin tablets for elderly patients should be due to extreme necessity, since the use of the drug can exacerbate chronic ailments, affect the body in an unpredictable way. If the doctor has prescribed a medicine to take, then elderly people need to drink pills very carefully, starting with the minimum dose, closely monitoring the body's reaction to the drug. If side effects occur, you should immediately stop taking the medicine, informing your doctor about it.

Pregnancy and lactation

Indomethacin can contribute to fetal developmental disorders, blockage of arterial ducts, myocardial insufficiency, bleeding due to a decrease in the number of platelets in the bloodstream, kidney dysfunction, obstruction of labor or premature birth. Based on the above facts, indomethacin tablets during pregnancy in the last stages and during breastfeeding are prohibited for use. During the first two trimesters, the remedy is prescribed only when absolutely necessary.

Side effects

Since the decrease in the production of prostaglandins and platelets when using the drug has a systemic effect on the entire body, the side effects of the drug can be many. These include:

From the side of the central, peripheral nervous systems and the brain: dizziness, weakness, fainting, drowsiness, anxiety or depression may develop.
On the part of the digestive tract: ulceration can be observed on the walls of the stomach and duodenum, bleeding, pain, nausea, vomiting, pain in the stomach.
From the hematopoietic system: thrombocytopenia, agranulocytosis, leukopenia, lack of erythrocytes in the blood.
From the genitourinary organs: urinary retention in the body, failure of the liver and kidneys, reduced fertility.

Still often there may be failures in the work of the myocardium, tachycardia, arrhythmia, weak pulse, signs of heart failure (acute), lowering of the upper pressure. If you are allergic to Indomethacin or additional components in the composition of the drug, a rash like urticaria, itching, signs of exfoliative dermatitis appear (infrequently). .

Contraindications

Indomethacin tablets should not be used for the following diseases:

bronchial asthma, or asthma caused by taking aspirin;
exacerbation of stomach ulcers or colitis;
allergies to drug components;
congenital heart diseases (atresia of the pulmonary artery, coarctation of the aorta);
severe damage to the liver and kidneys;
if the patient has a history of hemophilic congenital diseases;
proctological ailments, hemorrhoids, bleeding;
damage to the auditory or optic nerves;
hyperplastic sinusitis.

drug interaction

The combined use of indomethacin tablets with other nonsteroidal PVAs enhances their activity and may increase the risk of side effects. When interacting with diuretic and diuretic drugs, their effectiveness decreases. Simultaneous administration of Indomethacin with Paracetamol, gold preparations, cyclosporine, acetylsalicylic acid increases the risk of kidney damage. The combined action of indomethacin tablets and glucocorticosteroids, drugs containing ethanol, colchicine increases the likelihood of developing peptic ulcer.

Analogues

Anti-inflammatory drugs similar to Indomethacin, but with a different main component, are synonymous with it, but not similar. Analogues of a medicinal product containing the same active substance include:

Indotard;
Metindol;
Indobene;
Indovis;
Indocollier;
Indocide;
Indovis EU;
Indomethacin-Biosynthesis;
Movimed.

Price

Indomethacin is not an expensive medicine, the price of tablets is low, if desired, the drug can be bought in the online store from the catalog and ordered for home delivery. Prices for medicines in pharmacies in Moscow can be seen in the table below:

Video: Candles with indomethacin

Attention! The information provided in the article is for informational purposes only. The materials of the article do not call for self-treatment. Only a qualified doctor can make a diagnosis and give recommendations for treatment, based on the individual characteristics of a particular patient.

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Instructions for use of Indomethacin tablets - composition, indications, side effects, analogues and price

Is the drug "Indomethacin" (tablets). Due to its anti-inflammatory, analgesic and antipyretic effects, it is used to treat inflammatory diseases, eliminate pain, reduce swelling and restore joint mobility.

Description of the drug

The main active ingredient of the drug is indomethacin, which belongs to the derivatives of indoleacetic acid. The instruction describes the tablets inside the package of the drug "Indomethacin" as elements with a protective enteric coating, which allows the active substance to be released in the intestine, bypassing the stomach. The tablets are round, biconvex in shape, covered with a light brown shell on top.

Tablets come in several dosages: 25 mg, 50 mg and 100 mg of indomethacin. Available in packs of 10 or 40.

All dosage forms

In addition to tablets, there are other forms of the drug "Indomethacin" for oral use, for example, capsules with prolonged action with a dosage of 75 mg. For rectal administration, suppositories with a dose of 50 mg are used. For external use, an ointment of 5% and 10% and a gel of 3% were created.

Mechanism of action

Long-term use of the drug "Indomethacin" (tablets) does not exclude adverse reactions associated with sleep disturbance, dizziness, peripheral neuropathy, headache, agitation, irritability, fatigue. They are characterized by clouding of the cornea, conjunctivitis, hearing loss, tinnitus, high blood pressure, and edema.

Indomethacin sopharma: instructions for use and reviews

Indomethacin sopharma is a non-steroidal anti-inflammatory drug (NSAID).

Release form and composition

Dosage forms of Indomethacin sopharma:

enteric-coated tablets: round, biconvex, light brown on the outside and light yellow on the break [30 tablets in a blister, in a carton box of 1 or 45 blisters (for hospitals)];
rectal suppositories: torpedo-shaped, with a smooth surface, from white to yellowish, odorless, smooth and uniform on the cut (6 suppositories in a blister pack, 1 pack in a cardboard box);
ointment for external use: homogeneous, yellow in color, has a specific smell (40 g in a tube, 1 tube in a cardboard box).

Composition of 1 enteric-coated tablet:

active substance: indomethacin - 25 mg;
auxiliary components: lactose monohydrate, wheat starch, microcrystalline cellulose, povidone, anhydrous colloidal silicon dioxide, talc, magnesium stearate;
shell: solution of methacrylic acid and methyl methacrylate copolymer (1:1) - Eudragit L-12.5 (dry), solution of methacrylic acid and methyl methacrylate copolymer (1:2) - Eudragit S-12.5 (dry), dibutyl phthalate, diethyl phthalate, macrogol-400, macrogol-6000, castor bean seed oil, talc, titanium dioxide, dyes.

Composition of 1 suppository:

active substance: indomethacin - 50/100 mg;
auxiliary components: hard fat Estaram 8770 H 15 (Witepsol H 15), hard fat Estaram 8780 W 35 (Witepsol W 35).

Composition of 100 mg ointment:

active substance: indomethacin - 10 mg;
auxiliary components: petroleum jelly, lanolin, dimethyl sulfoxide, yellow beeswax, colloidal silicon dioxide, lavender oil.

Pharmacological properties

Pharmacodynamics

Indomethacin is a derivative of indoleacetic acid, has anti-inflammatory, antipyretic, analgesic and antiaggregatory effects. Able to suppress the activity of pro-inflammatory factors, reduce platelet aggregation.

Indomethacin, inhibiting cyclooxygenase I and II, disrupts the metabolism of arachidonic acid, reduces the number of prostaglandins in the focus of inflammation and healthy tissues, and suppresses the exudative and proliferative phases of inflammation. Effective for rheumatic and non-rheumatic pains.

Pharmacokinetics

When ingested, absorption occurs mainly through the mucous membrane of the small intestine and, to a lesser extent, through the gastric mucosa. The bioavailability of indomethacin when administered orally and rectally is 80-90%. The time to reach maximum plasma concentration is 1-2 hours. Plasma protein binding is 90-98% when administered orally and 90% when administered rectally. The substance is distributed in all organs and tissues of the body. Penetrates through the blood-brain and placental barriers. It penetrates into the joints through the synovial membrane, while the concentration of indomethacin in the synovial fluid increases. The half-life of the substance when using the tablet form of the drug is 2.6-11.2 hours, suppositories - 4.5 hours. The metabolism of indomethacin occurs mainly in the liver. Excreted by the kidneys (70%) and intestines (30%). Found in breast milk.

Ointment Indomethacin sopharma is absorbed through the skin, accumulating in the underlying tissues, joints, synovial fluid. Excretion also occurs mainly through the kidneys and partly through the intestines.

Indications for use

According to the instructions, Indomethacin Sopharma is indicated for symptomatic therapy to reduce inflammation and pain in the following conditions:

pain in inflammatory diseases of the musculoskeletal system [arthritis (rheumatoid, juvenile chronic, ankylosing, gouty, psoriatic), spondyloarthritis (Bekhterev's disease), Reiter's disease];
diseases of periarticular tissues (bursitis, tendonitis, tendovaginitis, tendobursitis);
injuries in athletes;
neuritis, discopathy, plexitis, radiculoneuritis;
dysmenorrhea.

Additionally for the ointment: osteoarthritis, ligament injuries, bruises, post-traumatic lesions of the musculoskeletal system.

Contraindications

Absolute contraindications:

ulcerative lesions of the stomach and duodenum;
inflammatory bowel disease (Crohn's disease, ulcerative colitis);
bleeding from the organs of the gastrointestinal tract (GIT), as well as intracranial bleeding;
congenital heart disease (severe tetralogy of Fallot, severe coarctation of the aorta, pulmonary atresia);
condition after recent coronary artery bypass grafting;
severe heart failure;
renal failure with creatinine clearance (CC) ˂ 30 ml/min;
active liver disease, liver failure;
blood clotting disorders (hemophilia, prolonged bleeding time, tendency to bleed;
anemia, leukopenia;
hyperkalemia (confirmed);
age up to 14 years (for tablets), up to 15 years (for suppositories);
hypersensitivity to any of the components of the drug, acetylsalicylic acid or other NSAIDs.

ischemic heart disease, chronic heart failure;
cerebrovascular diseases;
hyperlipidemia, dyslipidemia;
diabetes;
thrombocytopenia;
peripheral arterial disease;
arterial hypertension;
smoking;
kidney disease with CC ˂ 60 ml / min;
hyperbilirubinemia;
cirrhosis of the liver with portal hypertension;
ulcerative diseases of the gastrointestinal tract in history;
presence of Helicobacter pylori infection;
prolonged use of NSAIDs;
severe somatic diseases;
mental disorders;
depression;
epilepsy;
parkinsonism;
elderly age;
alcohol abuse.

Ointment for external use

Absolute contraindications:

damage to the skin at the site of application of the drug;
pregnancy and lactation;
age up to 14 years;
increased sensitivity to any of the components of the drug, as well as rhinitis, urticaria, bronchial asthma and angioedema, which developed during the use of NSAIDs.

Relative contraindications:

allergic reactions;
dysfunction of the kidneys and liver (in the case of using the ointment on large areas of the skin);
erosive and ulcerative diseases of the gastrointestinal tract;
blood clotting disorders;
exacerbation of hepatic porphyria;
a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs;
elderly age.

Instructions for use Indomethacin sopharma: method and dosage

Pills

Indomethacin sopharma tablets are taken orally after meals with plenty of water.

The recommended initial dose of the drug is 25 mg 2-3 times a day. If necessary, it is increased to 50 mg 3 times a day. The maximum daily dose is 200 mg. With prolonged use of the drug, its dose should not exceed 75 mg per day.

To stop an acute attack of gout, a single dose of 100 mg of the drug is recommended, then the treatment is continued, taking 50 mg 3 times a day until the pain disappears.

Indomethacin Sopharma should be taken at the lowest effective dose for the lowest possible course.

Suppositories rectal

Suppositories are used rectally (introduced into the rectum) 50 mg 2 times a day, or 100 mg 1 time a day. The maximum daily dose is 200 mg. The duration of the drug should not exceed 7 days.

Ointment for external use

Ointment Indomethacin Sopharma is used externally. Adults apply the drug in a thin layer (strip of ointment 4-5 cm), rubbing lightly into the skin, 3-4 times a day; children over 14 years old - a thin layer (strip of ointment 2-2.5 cm) 2-3 times a day.

The interval between applications should be at least 6 hours. Duration of application - 7-10 days.

The total daily amount of ointment squeezed out of the tube should not exceed 15 cm for adults and 7.5 cm for children.

Side effects

Rectal tablets and suppositories

digestive system: abdominal pain, NSAID gastropathy, nausea, vomiting, diarrhea, anorexia, heartburn, bleeding, liver dysfunction, toxic hepatitis, fulminant hepatitis; with prolonged use of large doses of the drug - ulcerative stomatitis, ulceration of the gastrointestinal mucosa;
central nervous system: dizziness, headache, agitation, drowsiness, fatigue, peripheral neuropathy, sensory disturbances, including paresthesia, disorientation, insomnia, depression, irritability, anxiety, memory disorder, psychotic reactions;
cardiovascular system: development or aggravation of chronic heart failure, tachyarrhythmia, edematous syndrome, increased blood pressure;
sensory organs: tinnitus, hearing loss, taste disturbance, diplopia, blurred vision, corneal clouding, conjunctivitis;
urinary system: edema, proteinuria, hematuria, interstitial nephritis, nephrotic syndrome, papillary necrosis;
hematopoietic and hemostasis system: bleeding, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura;
allergic reactions: skin rash, itching, urticaria, angioedema, bronchospasm, photosensitivity, Lyell's syndrome, Stevens-Johnson syndrome, erythema nodosum, anaphylactic shock;
laboratory parameters: leukopenia, agranulocytosis, thrombocytopenia, glucosuria, hyperglycemia, hyperkalemia;
local reactions (when using rectal suppositories): itching, burning, heaviness in the anorectal region, exacerbation of hemorrhoids;
other: increased sweating, aseptic meningitis (more common in patients with autoimmune diseases), aplastic anemia, autoimmune hemolytic anemia.

Ointment for external use

Itching, burning, rash, peeling, dryness and hyperemia of the skin, irritation, contact dermatitis, exacerbation of psoriasis, local edema, vesicular rash, shortness of breath, angioedema are possible.

When used on large areas of the skin, systemic side effects may develop.

Overdose

Symptoms of an overdose of Indomethacin sopharma: nausea, vomiting, dizziness, severe headache, disorientation, memory impairment. In severe overdose - paresthesia, numbness of the extremities, convulsions.

In case of inadvertent ingestion of the drug in the form of an ointment, burning, salivation, nausea, and vomiting are possible. Washing of the oral cavity and stomach and symptomatic treatment are indicated.

special instructions

Rectal tablets and suppositories

During the period of drug therapy, the picture of peripheral blood and the functional state of the liver and kidneys should be monitored.

If it is necessary to determine 17-ketosteroids, it is advisable to cancel Indomethacin Sopharma 48 hours before the study in order to avoid distorting its results.

If signs of hypersensitivity appear, the drug should be discontinued.

Due to the fact that indomethacin can mask the symptoms of acute inflammation, it is recommended to exclude a bacterial infection before starting therapy. The risk of developing hyperkalemia is higher with renal failure, age over 65 years, co-administration of β-blockers, ACE inhibitors, potassium-sparing diuretics. In such patients, the level of serum potassium is recommended to be kept under control.

Women of reproductive age are at risk of reversible fertility suppression while taking Indomethacin Sopharma.

Ointment for external use

Do not apply Indomethacin Sopharma ointment to broken or infected areas of the skin.

It is recommended to avoid getting the ointment in the eyes, mouth, mucous membranes and open wounds. In case of accidental contact, it is advisable to rinse the affected area with plenty of water or 0.9% sodium chloride solution until complaints (redness, burning, lacrimation, pain) decrease or disappear.

Treatment should be interrupted if a rash occurs. When used for more than 10 days, it is recommended to control the content of leukocytes and platelets.

Influence on the ability to drive vehicles and complex mechanisms

At the time of use of rectal suppositories and Indomethacin Sopharma tablets, one should refrain from driving vehicles and other complex mechanisms that require quick psychomotor reactions.

drug interaction

other NSAIDs, acetylsalicylic acid, glucocorticosteroids, alcohol, colchicine, corticotropin: the risk of bleeding from the gastrointestinal tract increases;
diuretics: their effectiveness decreases;
potassium-sparing diuretics: the risk of hyperkalemia increases;
uricosuric and antihypertensive drugs: their effectiveness decreases;
indirect anticoagulants, antiplatelet agents, thrombolytics (alteplase, streptokinase, urokinase): their effect is enhanced;
glucocorticosteroids, NSAIDs, estrogens, acetylsalicylic acid: the side effects of these drugs increase;
sulfonylurea derivatives: their hypoglycemic effect is enhanced;
paracetamol, cyclosporine, gold preparations: the risk of nephrotoxic effects increases;
methotrexate, lithium preparations, digoxin: their toxicity increases due to an increase in plasma concentration;
cefamandol, cefoperazone, cefotetan, valproic acid, plicamycin: the risk of hypoprothrombinemia and bleeding increases;
zidovudine: its toxic effect increases;
antacids, cholestyramine: reduce the absorption of indomethacin;
myelotoxic drugs: increase the manifestation of hematotoxicity of indomethacin;
quinolones: increased risk of seizures;
insulin, oral hypoglycemic drugs: their hypoglycemic effect is enhanced.

With topical application of the drug, no interactions were observed.

Analogues

Analogues of Indomethacin sopharma are Indocollir, Metindol retard.

Terms and conditions of storage

Store in a dry place, away from light, at a temperature not exceeding 25 °C. Keep away from children.

Shelf life - 5 years (for tablets), 3 years (for suppositories and ointments).

After the first opening of the tube, the shelf life of the ointment is 30 days.

Terms of dispensing from pharmacies

Tablets and suppositories are available by prescription, ointment - without a prescription.

The instruction to Indomethacin indicates that this drug is one of the most active non-steroids. It has an anti-inflammatory and analgesic effect, and also delays the production of active biological substances that are responsible for the development of pain and swelling in the area of the inflammatory process.

Also, this drug inhibits the aggregation of blood clots, increases the range of motion and reduces morning stiffness. The anti-inflammatory effect is observed by the end of the first week of indomethacin use.

Due to its aforementioned actions, Indomethacin is widely used in gynecology.

Indications for use

Indomethacin according to the instructions is prescribed in the following situations:

Systemic use: articular syndrome (osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis), neuralgia, pain in the spine, traumatic inflammation of the joints and soft tissues, myalgia, rheumatism, diffuse connective tissue diseases, infectious and inflammatory diseases of the upper respiratory tract, prostatitis.
External use: traumatic inflammation of soft tissues and joints, myalgia, neuralgia, pain in the spine, articular syndrome (gout, ankylosing spondylitis, osteoarthritis, rheumatoid arthritis).
Topical application: inhibition of miosis at the time of surgery, prevention of inflammation during surgery on the anterior segment of the eye and for cataracts.

As for Indomethacin in gynecology, it is used in the complex treatment of adnexitis, painful menstruation and cystitis.

Contra

Indomethacin tablets, suppositories, injections, ointments and eye drops should not be used for:

peptic ulcer of the stomach and duodenum;
parkinsonism;
gastrointestinal bleeding;
hypertension (high blood pressure);
epilepsy;
violations of the hepatic and renal function;
bone fractures;
mental disorders;
hypersensitivity to the components of the drug.

In addition, Indomethacin suppositories cannot be used for proctitis and hemorrhoids. Women during pregnancy and lactation (breastfeeding), as well as children under 10 years old, this drug is also contraindicated.

Mode of application

Candles Indomethacin is used rectally - one suppository is put into the rectum at night. There are times when candles are taken twice a day - in the morning and at night. Medical specialists say that combined treatment is considered the most effective - one or two tablets per day and one suppository at night.

The solution for intramuscular injection is intended exclusively for adults - 60 milligrams once or twice a day.

Indomethacin in the form of a gel or ointment is applied to the painful area (a strip three to four centimeters long) two to three times a day.

Eye drops are intended only for the adult category of patients - one drop three to four times a day.

Indomethacin in gynecology is prescribed individually (it all depends on the cause of the disease, the severity of the disease, etc.).

Side effects of indomethacin

According to the instructions, Indomethacin can provoke some side effects:

From the peripheral and central nervous system - headache, dizziness, fatigue, depression, drowsiness, fainting, peripheral neuropathy, involuntary muscle movements, muscle weakness, mental disorders, sleep disorders, dysarthria, paresthesia, parkinsonism.
From the gastrointestinal tract - anorexia, nausea, vomiting, discomfort and pain in the abdomen, diarrhea or constipation, perforation and bleeding of the gastrointestinal tract, erosive and ulcerative diseases, intestinal strictures, gastritis, stomatitis, flatulence, hepatitis, jaundice.
From the side of the cardiovascular system - increased blood pressure, edema, tachycardia, arrhythmia, chest pain, arterial hypotension, palpitation, hematuria, congestive heart failure.
From the urinary system - nephrotic syndrome, proteinuria, impaired renal function, interstitial nephritis, renal failure.
On the part of the sense organs - diplopia, impaired visual perception, periorbital and orbital pain, deafness.
From the hematopoietic system - petechiae, leukopenia, purpura, hemolytic and aplastic anemia, DIC syndrome, thrombocytopenia.
From the side of metabolism - hyperkalemia, glucosuria, hyperglycemia.
Allergic reactions - urticaria, pruritus, erythema nodosum, angiitis, skin rash, Stevens-Johnson syndrome, exfoliative dermatitis, erythema multiforme, hair loss, a sharp drop in blood pressure, acute respiratory distress, angioedema, anaphylactic reactions, bronchial asthma, dyspnea, edema lungs.
Others - hot flashes, vaginal bleeding, increased sweating, gynecomastia, tightness or enlargement of the mammary glands, nosebleeds.

Anti-inflammatory drugs are used to relieve inflammation itself, have an analgesic effect, lower fever, and remove fever. Drugs of the NSAID group (non-steroidal) have their own advantage over others - the absence of undesirable properties of steroids. Indomethacin is a drug of this group, the appointment of which, in some situations, is inevitable.

The drug Indomethacin, composition, purpose of use

This medicine can be released in various forms (tablets, suppositories, ointments), there are conflicting opinions about its positive effect, as it gives a strange kind of consequences.

The first thing to note is that this remedy should not be used without the recommendation and prescription of a doctor. The drug belongs to the group of NSAIDs, in addition, it is a manufacturer of indoleacetic acid. Its actions are aimed at coping with the inflammatory process, reducing pain at the site of the lesion. Indomethacin tablets block the work of inflammatory pathogens, and also reduce platelet aggregation. The active substance is indomethacin. In various forms of the drug, other excipients may be used.

Absorption is quite fast, the process of disintegration of the drug, its metabolism, is carried out in the liver.

This medicine is used to improve the condition of a patient who suffers from rheumatic pain syndromes. But it is worthwhile to understand that without a doctor's prescription, it is not recommended to buy drugs of this group, since side effects that contribute to poor health are possible. There are options for admission, both inside and outside. Depending on the diagnosis and personal tolerance, the doctor prescribes the best option, there are times when the drug is used in several forms at once. The use of indomethacin can be prescribed for such ailments:

neuralgia;
Pain in the spine and other joints;
Various kinds of traumatic inflammation.

These ailments cause serious pain, in such cases, the specialist can offer indomethacin ointment, for quick external use. If the patient had surgical interventions, then in order to relieve inflammation, such a drug (topical application) can be used.

There are also a number of reasons why you will be prescribed an NSAID drug:

Inflammation associated with joint deformity, various types of arthritis, which we advise you to read in more detail;
In cases of soft tissue damage, but only if it is rheumatic in nature;
Assign in cases and complex therapy, but again, in order to relieve pain and inflammation itself.

Forms releasing, how to use the drug correctly

This medicine, as mentioned above, can be produced in different forms, this is necessary so that the doctor can choose a high-quality course of treatment for the patient, directions for eliminating pain and inflammation in places of direct localization. Prices for such a drug may vary, depending on what you buy - ointment, or tablets. But you should understand that if you are prescribed pills, you do not need to replace them with something else.

Today, we can distinguish the following forms of release of the drug:

Eye drops. They are rarely prescribed, but they do occur. The price for them is about 200-220 rubles;
Indomethacin suppositories. They can be prescribed in cases of severe pain in the spine, with severe inflammation of soft tissues (under conditions of a traumatic nature), with pain in the joints;
Tablets / dragees. The most common treatment option. It is in this form that the doctor prescribes this drug. But here there is another opinion that it is better to use candles, or ointments, for a quick effect of eliminating pain and inflammation. Tablets are best used in a complex method of treatment, then the effect will be 100%. Issue price -30-45 rubles;
Capsules. Same as tablets. They are prescribed, but it is better to do it in combination. They have an advantage over tablets - they dissolve quickly;
Ointment. Used in cases of severe pain in the joints and back. The ointment is applied to the site of the lesion. The effect comes after a minimum amount of time. It should be used as prescribed by a doctor.

Speech about self-medication with such a drug can not even be. Therefore, the specialist himself will prescribe a course of treatment for you, determine the dosage. Instructions for the use of Indomethacin are attached to any form of release, but it is better to take the drug based on the instructions prescribed by the doctor:

Pills. Their number and duration of use depends on the severity of the disease. In general, an adult should take about 25 mg of such a substance, and then breaking it down into 2-3 doses. It is possible to increase the dosage up to 50 mg. After 4 weeks of treatment, with a positive outcome, the dosage begins to be reduced. In no case should you exceed 75 mg of the drug per day. Since the drug is quite serious, you should not drink it on an empty stomach, use it after meals;
The use of Indomethacin suppositories is prescribed for severe back pain. It should be understood that the drug enters the body through the rectum, so it is worth emptying the intestines before using the drug directly. Most often, an adult is prescribed only 100 mg of the drug, 1 candle. Possible option two times 50 mg. If more acute, then they can raise the dosage, as much as 200 mg;
Injections. They are used already in the most serious forms of the disease. Assign 60 mg, injected intramuscularly. Such a course of treatment is about 2 weeks, while the injection itself is done 1 time in 1-2 days.

Rectal suppositories

Indomethacin rectal suppositories have been used in medicine for a long time, they have a number of properties necessary in the treatment of diseases of the spine and other joints:

Anesthetize;
Their action is aimed at reducing the inflammatory process;
They have the ability to relieve heat.

Positive feedback, candles received during their use in such diseases:

Various kinds of arthritis, osteoarthritis.
Joint diseases;
Neuralgia, various pains in the spine;
During the treatment of soft tissues that have suffered due to various kinds of injuries.

Instructions for candles can tell you how much to use this drug, but without the recommendation of a doctor, this is not recommended. As practice shows, with severe acute manifestations of pain and inflammation, the patient can be prescribed 2 suppositories per day. The dosage of the substance is from 50 mg to 100 mg. It should be understood that more than 200 mg per day is not recommended.

After a course of treatment, the dose may be reduced, and the drug may be prescribed as a prophylactic.

Instructions for the use of candles states that this drug has side effects and a number of contraindications. Side effects include:

Vomiting, nausea (from the gastrointestinal tract);
Constant drowsiness, dizziness, irritability, depression (from the nervous system);
Shortness of breath appears, pain in the heart is possible (from the side of the cardiovascular system);
Pain in the lower back (from the genitourinary system);
Allergies are possible.

Despite the fact that these candles have a good effect, and easily cope with their functions, there are a number of contraindications that should be taken into account so as not to provoke other diseases:

Immediate personal intolerance to the drug, hypersensitivity to the main substance;
All degrees of ulcer;
Problems with the liver and kidneys;
Inflammation of the rectum, no matter what stage;
Hemorrhoids, as well as inflammation of the colon.

The use of indomethacin in gynecology also has a place to be. This is due to the fact that almost all diseases of the female genital organs carry severe back pain, so doctors safely prescribe this drug.

Its direct function in this matter is to relieve pain. Due to the fact that the suppository of the drug is quickly absorbed, relief comes almost instantly. In addition, the drug relieves inflammation, which is also necessary for a number of ailments.

The use of indomethacin suppositories in gynecology is logical and possible with such diseases:

In gynecology, it is used for cystitis. In this situation, it is prescribed with a number of other tablets (antibiotics);
Candles with indomethacin in gynecology are relevant in the postoperative period of time in order to prevent the formation of adhesions;
Myoma of the uterus.

Instructions for the use of suppositories in gynecology should be written out by the doctor himself, since in such a situation self-medication is strictly prohibited. Most often, during treatment, the patient is not prescribed more than 1-2 suppositories per day. This amount of the drug allows you to maintain the correct therapeutic concentrate in the blood.

Ointment Indomethacin

What helps indomethacin ointment has long been known. It is prescribed in cases of problems with the joints, with pain in the spine, as well as pain in the muscles. The composition of such a drug includes not only the main substance, but also auxiliary (dimexide, trolamine).

Biosynthesis ointment is applied directly to the affected area. It has not only an analgesic effect, but also relieves inflammation. But it should be understood that its use should be carried out 2-3 times a day, no more. The ointment is absorbed through the pores of the skin, and carries out its action.

The main substance has a quick analgesic effect. But it should be understood that there are certain contraindications that should be taken into account before using the ointment:

Immediate sensitivity to the drug.

It is important to understand that before you start using the ointment, make sure that you are not taking other NSAIDs. The ointment itself should be applied exclusively to the site of damage. In case of contact with eyes, rinse immediately.

The use of indomethacin ointment is carried out according to a certain scheme: the daily norm of the ointment should not be more than 15 cm squeezed out of the tube. Apply only to affected areas, in a thin layer, 2-3 times a day.

The instructions for the ointment describe that during the application of such an ointment, side effects may be noticed:

Inflammation at the site of application of the ointment;
Dryness and peeling;
Edema.

Tablets, how can I replace indomethacin

Indomethacin tablets instructions for use states that it should be used at 25 mg, 2-3 times a day, but only after a doctor's prescription. The dose of application can be increased, but this is done only after visiting a doctor. Up to 50 mg per day 3 times. The daily rate of such a drug should not exceed 200 mg.

Indomethacin tablets are used only as directed by a doctor. Tablets can also have side effects associated with a violation of various systems of the human body. Also, it is worth noting that indomethacin biosynthesis is not always combined with other drugs. For example, it should not be used in conjunction with NSAIDs of the group.

If you are not satisfied with the price for this drug, or it is not available in the pharmacy, you may be offered analogues to indomethacin: Metindol Retard, Indocollir and others.

It should be understood that absolutely all treatment with drugs of the NSAID group should be carried out only with the filing of the attending physician.

Patient reviews, drug prices

Indomethacin Berlin Chemi is a fairly affordable remedy. In the pharmacies of the city it can be found at a price of 200-250 rubles. The price depends on the pharmacy itself, as well as on the manufacturer. Sold without a prescription.

Ivan Nikolaevich, 56 years old. Feedback on the ointment from my friends is positive. But I did not buy it because there was no doctor's prescription. In the pharmacy, I was also advised to buy an ointment to relieve back pain. Bought. After applying the ointment 3 times, I felt relief. I use only according to the instructions.
Oleg, 23 years old. From what the drug helps - I know, but I personally did not buy it. After I went in for sports, frequent injuries forced me to see a doctor, I was prescribed Indomethacin, for external use. I was surprised that its action is instantaneous. Now, in cases of severe pain in the knees or back, I apply this ointment, but only on the recommendation of a doctor.

Indomethacin is a non-steroidal anti-inflammatory drug with analgesic and antipyretic effects, available in the form of tablets, rectal suppositories (candles), ointments, eye drops and injections.

The anti-inflammatory effect is observed by the end of the first week of indomethacin use. With prolonged therapy, it has a desensitizing effect on the body. When applied topically, it eliminates pain, reduces swelling and erythema.

Indomethacin is one of the most active drugs from the group of non-steroidal anti-inflammatory drugs. Due to the action of its main component in the human body, the biosynthesis of prostaglandins from arachidonic acid is inhibited, the inflammatory process decreases and the swelling of the affected tissues is removed.

Indomethacin photo suppositories

Additionally, Indomethacin delays the production of active biological substances responsible for the development of pain and swelling in the area of the inflammatory process. The drug inhibits the aggregation of blood clots, increases the range of motion and reduces morning stiffness.

Indomethacin in the form of suppositories provides a reduction or cessation of pain in rheumatism (articular pain without movement or in movement, relieving numbness and immobility of the joints in the morning, reducing swelling of the joints, increasing the range of motion. With postoperative and post-traumatic inflammation, it helps relieve pain, reduce swelling).

Indications for the use of Indomethacin

For topical use:

inhibition of miosis during surgery;
prevention of the inflammatory process during operations on the anterior segment of the eye and for cataracts.

For outdoor use:

articular syndrome (including rheumatoid arthritis, arthrosis or osteoarthritis, ankylosing spondylitis, gout);
pain in the spine;
neuralgia;
myalgia;
traumatic inflammation of soft tissues and joints.

For systemic use:

diffuse connective tissue diseases;
dysmenorrhea;
neuralgia;
articular syndrome;
myalgia;
traumatic inflammation of the joints and soft tissues;
pain in the spine;
as an additional remedy for adnexitis, cystitis, prostatitis, as well as infectious and inflammatory diseases of the upper respiratory tract.

Instructions for use Indomethacin, dosage

The initial dosage of the drug usually begins with 0.025 g (25 mg) 2-3 times a day (adults), then, depending on tolerance, increase the daily dose to 100-150 mg per day (in 3-4 doses).

Attacks in acute form - 0.05 g of the drug three times a day;
- Prevention of exacerbations - 0.025 g twice a day.

The maximum daily dose of Indomethacin is 200 mg.

When the desired therapeutic effect is achieved, treatment with Indomethacin is continued for 4 weeks at the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg.

Indomethacin injections

For the treatment of acute conditions or relief (removal) of exacerbation of a chronic process, 60 mg of indomethacin is administered intramuscularly 1-2 times a day.
The duration of intramuscular administration of the drug is 7-14 days. Further therapy is carried out with the use of tablets or suppositories.

Candles Indomethacin

Rectal suppositories are used for exacerbations of chronic processes or acute conditions. In this case, the standard dosage is 1 suppository (0.05 or 0.1 g) 2 times a day. It is necessary to ensure that the maximum daily dose does not exceed 0.2 g.

For maintenance treatment, suppositories are used at a dosage of 0.05-0.1 g once a night. Rectally, the suppository is inserted after a natural bowel movement deep into the rectum.

Indomethacin ointment, according to the instructions for use, is applied to the affected area with a thin layer. For a day, you can not exceed the maximum dosage - up to 15 centimeters of the product squeezed out of the tube. For children, the maximum dose cannot exceed 7 centimeters.

Indomethacin is usually prescribed for a long time. Premature discontinuation may lead to the resumption of manifestations of the disease. The duration of the course of treatment depends on the severity of the disease and is determined individually by the attending physician.

Contraindications

hypersensitivity to the active substance of the drug;
gastrointestinal ulcer in the acute phase;
"aspirin triad";
hematopoietic disorders;
severe violations of the liver and / or kidneys;
severe forms of CHF, arterial hypertension, pancreatitis;
3rd trimester of pregnancy;
children's age up to 14 years;
for rectal use: proctitis, recent bleeding from the rectum.

Side effects:

nausea, vomiting, gastropathy, heartburn, loss of appetite, liver dysfunction, abdominal pain. When used in large doses, long-term use - ulceration of the gastrointestinal mucosa.
dizziness, headache, agitation, insomnia, fatigue, irritability, depression, drowsiness, peripheral neuropathy.
tachyarrhythmia, arterial hypertension, heart failure.
tinnitus, hearing loss, diplopia, taste disturbance, corneal clouding, blurred vision, conjunctivitis.
nephrotic syndrome, impaired renal function, hematuria, proteinuria, necrosis of the renal papillae, interstitial nephritis, renal failure.
hematuria, bleeding, thrombocytopenia.
skin rash, urticaria, itching, angioedema, bronchospasm, rarely - Lyell's syndrome, anaphylactic shock, erythema nodosum.
autoimmune hemolytic anemia, aplastic anemia, aseptic meningitis (more often in patients with autoimmune diseases), edematous syndrome, increased sweating. Possible water and electrolyte retention, swelling.
itching, burning, dermatitis, feeling of heaviness and bleeding in the anorectal region, exacerbation of hemorrhoids.

Overdose

When using Indomethacin in amounts significantly exceeding those prescribed, vomiting, migraine, disorientation, dizziness may occur.

Use in children

Contraindicated in children and adolescents under the age of 14 years.

Use during pregnancy and lactation

Indomethacin is contraindicated in the 3rd trimester of pregnancy. In the 1st and 2nd trimesters of pregnancy, as well as during lactation (breastfeeding), the use is not recommended.

Analogues of the drug Indomethacin, list

Structural analogues for the active substance:

Indobene;
Indovis EU;
Indocollier;
Indotard;
Indocide;
Metindol.

It is important to understand that the instructions for use of Indomethacin, the price and reviews do not apply to analogues and cannot be used for prescribing, replacing or other actions with medicinal preparations. The replacement of Indomethacin with analogues should be carried out by a specialist, after studying the medical history and tolerability of side effects.

With any form of joint disease, our brain begins to receive an unceasing pain signal. The drug Indomethacin can provide treatment in a calm mode, the active substance of which is able to penetrate into the tissues of the body and exert an analgesic and anti-inflammatory effect on the affected area.

Composition and form of release

On the pharmaceutical market, Indomethacin is presented in the form of four dosage forms:

Biconvex, round tablets, white on a break, covered with an enteric film. Tablets are packaged in 10 and 30 pieces in blisters, which are placed in 1, 2, 3, 4, 5, 6, 8, 10 packs in carton packs. The second packaging option is plastic jars with tablets in the amount of 10, 20, 30, 40, 50, 60, 100 pieces.
Rectal suppositories. They have a white-yellow or white-cream color, a slight smell, and a torpedo-shaped shape. Suppositories are packaged in blisters: 100 mg - five pieces per pack - two in a carton; 50 mg, 6 pieces per pack - one in a carton box; 50 mg, 5 or 3 pieces per pack - two in a carton box.
Ointment 10% for external use. It has a specific smell, color from light yellow to dark yellow with a greenish tint. The ointment is sold in aluminum tubes of 15, 30, 40 g, glass jars of 10, 15, 20, 25, 30, 40 g or plastic tubes of 30 g.
Gel 10 and 5% for external use. It has a slight smell of alcohol and a yellow homogeneous structure; it is sold in aluminum tubes of 40 g each.

The active substance of all dosage forms of the drug is of the same name with the trade name - Indomethacin. The composition is presented in the table:

	Weight, mg
Pills
Indomethacin
Auxiliary components: lactose monohydrate, potato starch, microcrystalline cellulose, povidone, magnesium stearate
suppositories
Indomethacin
Auxiliary components: semi-synthetic glycerides, cetyl alcohol

Indomethacin, 1 g
Auxiliary components: dimethyl sulfoxide, macrogol 400, macrogol 1500, glycerol

Indomethacin
Auxiliary components:	Propylene glycol, carbomer, ethanol, macrogol 400, sodium benzoate.

Pharmacodynamics and pharmacokinetics

Instructions for use of Indomethacin indicate that the drug has analgesic, antiaggregatory, antipyretic and anti-inflammatory effects. The active component of the composition refers to derivatives of indoleacetic acid, drugs of the group of non-steroidal anti-inflammatory drugs. The effectiveness of the drug is associated with an inhibitory effect on the cyclooxygenase enzyme, which inhibits the metabolic conversion of arachidonic acid and reduces the synthesis of prostaglandins (inflammatory mediators).

The use of the drug inhibits platelet aggregation, when administered enterally, it reduces the severity of joint pain during movement and rest, morning stiffness and swelling, and increases motor volume. After 5-7 days from the start of treatment with the drug, its anti-inflammatory effect is manifested. External application of the gel and ointment relieves pain, swelling, and reduces the manifestations of erythema.

Oral forms of the drug are rapidly absorbed from the gastrointestinal tract, reaching a maximum concentration after two hours. Metabolism occurs in the liver after enterohepatic recirculation. Metabolites are desmethyl, desbenzoyl and desmethyl-desbenzoyl compounds. The elimination half-life is 4.5 hours, 60% of the dose is excreted. Excretion is carried out by the kidneys and intestines. Candles are absorbed in the rectum, have 85% bioavailability and 90% binding to albumin.

Indications for the use of Indomethacin

neuralgia of various origins;
myalgia;
pain in the spine;
painful diffuse conditions of the connective tissue;
dysmenorrhea;
inflammatory infectious processes characteristic of prostatitis, adnexitis, pathologies of ENT organs, cystitis;
rheumatism.

Direct indications for ointment and gel Indomethacin are the following conditions:

inflammatory processes arising from trauma and occurring in soft tissues and joints;
articular syndrome, including osteoarthritis, gout, ankylosing spondylitis, rheumatoid arthritis;
pain in the spine;
myalgia;
neuralgia;
stop pupil constriction during surgery;
prevention of inflammation after cataract surgery and in the anterior segment of the eye;
radiculitis;
inflammatory damage to ligaments and tendons;
bursitis;
sciatica;
lumbago;
osteochondrosis with radicular syndrome.

Method of application and dosage

The list of indications for the appointment of Indomethacin includes many different conditions, each of which may include several stages. In addition, the individual condition of the patient requires professional consideration when prescribing the remedy. So a specialist should prescribe a medicine and develop a treatment regimen, which will take as a basis the standard settings of the manufacturer's instructions.

Indomethacin tablets

Tablets are taken orally during meals or immediately after meals. The initial standard dose is 25 mg, the number of applications is 2-3 times throughout the day. If the desired therapeutic effect cannot be achieved, the dose is increased to 50 mg, 2-3 times a day. The maximum cumulative dosage is 200 mg Indomethacin per day. When a therapeutic effect is achieved, the reception continues for four weeks. The dosage level remains the same, according to the decision of the doctor, a reduction is acceptable. If the treatment is long, then the daily dose is a maximum of 75 mg.

Indomethacin suppositories

According to the instructions Indomethacin suppositories are designed for rectal use. The introduction of a candle must be carried out after cleansing the intestines, before going to bed. In order for the active ingredient of the drug to be absorbed as much as possible, you need to push the suppository as far as possible into the rectum. The standard scheme provides for a three-time use of 50 mg suppositories or a single administration of a suppository with an active ingredient content of 100 mg. With severe pain (gout attack), the doctor may increase the dosage to 200 mg per day.

Gel and ointment

Dosage forms of ointment and gel are designed for rubbing and application into the skin area, which is located above the pain zone. To do this, they are applied in a thin layer on clean, undamaged skin. The drug with a concentration of the active substance of 5% is applied 3-4 times a day. According to the instructions, if the concentration is 10%, then the applications are carried out 2-3 times a day. The dosage volume for an adult patient is determined by the centimeters of the drug squeezed out of the tube. One dose is approximately 4-5 cm3. The maximum daily volume is 15-20 cm3. Children's doses are less than half.

special instructions

The instruction says that the drug should be used with caution. Special instructions for use:

During treatment, it is required to control the parameters of the blood, liver, kidneys.
Tablets should be taken with food, otherwise the risk of developing complications from the gastrointestinal tract (bleeding, ulcers, erosion) increases.
Candles from prostatitis are used if there is no damage to the rectum. In gynecology, suppositories are also used rectally, they cannot be inserted into the vagina.
The gel and ointment are applied to intact skin, avoid contact with eyes and mucous membranes.
During therapy with Indomethacin, alcohol is prohibited, because the likelihood of bleeding increases.

During pregnancy

The drug Indomethacin (Indometacinum) in the form of tablets and suppositories is contraindicated during pregnancy and lactation. Gel and ointment can not be used only in the third trimester of bearing a child. In the first and second trimesters of pregnancy plus lactation (breastfeeding), it is permissible to use these medication formats with caution.

In childhood

According to the instructions, oral and rectal forms of the drug are contraindicated for use by children and adolescents under 14 years of age. The external form can be used in babies older than one year, but with caution, if indicated and under the strict supervision of doctors. It is not recommended to exceed the dosage of the drug and the duration of the course of treatment.

drug interaction

The instructions for Indomethacin indicate its drug interaction with other drugs. These are combinations:

It is not recommended to use Difluniaz, Akrikhin and non-steroidal anti-inflammatory drugs in parallel with the drug.
The drug enhances the toxicity of lithium preparations.
The combination of the drug with glucocorticoids, corticotropin, ethanol, colchicine, thrombolytics, anticoagulants, antiplatelet agents, Warfarin, Prednisolone can enhance the manifestations of bleeding from the gastrointestinal tract.
Paracetamol increases the neurotoxicity of the drug.
The drug enhances the hypoglycemic effect of drugs that lower blood sugar levels, insulin, nephrotoxicity of gold preparations, Cyclosporine.
The drug reduces the effectiveness of potassium-sparing diuretics, leading to hypokalemia. A similar effect is observed in relation to antihypertensive and uricosuric drugs.
The combination of Indomethacin with Plikamycin, Cefamandol, valproic acid, Cefoperazone, Cefotean increases the risk of bleeding, hypoprothrombinemia.
The drug enhances the manifestation of side effects of estrogen, increases the toxicity of Zidovudine, hematotoxicity of myelotoxics.
Antacids and cholestyramine can reduce the absorption of the active ingredient.

Side effects of indomethacin

Indomethacin may cause side effects. These, according to the instructions, include:

jaundice, abdominal pain, flatulence, vomiting, nausea, anorexia, gastrointestinal bleeding, gastritis, stomatitis, diarrhea, constipation;
skin hyperemia;
perforation of the digestive tract, erosion, ulcers, intestinal strictures, hepatitis;
anxiety, muscle weakness, dysarthria, fainting, headache, dizziness, parkinsonism, involuntary muscle contractions, depression, convulsions, paresthesia, peripheral neuropathy, fatigue, drowsiness, mental disorders, sleep disturbances;
arrhythmia, hematuria, edema, chest pain, congestive heart failure, arterial hypotension, increased pressure, tachycardia, palpitation;
aplastic or hemolytic anemia, petechiae, purpura, leukopenia, DIC, thrombocytopenia, ecchymosis (bruising);
renal failure, impaired renal function, interstitial nephritis, nephrotic syndrome, proteinuria;
periorbital pain, deafness, tinnitus, diplopia, visual impairment, hearing impairment;
hyperglycemia, hyperkalemia, glucosuria;
hair loss, allergies, dyspnea, itching, rash, pulmonary edema, urticaria, Stevens-Johnson syndrome, angiitis, bronchial asthma, anaphylaxis, exfoliative dermatitis, erythema nodosum or multiforme, Lyell's syndrome, a sharp drop in pressure, angioedema, respiratory distress;
gynecomastia, hot flashes, vaginal bleeding, breast tightness;
hyperhidrosis;
glycosuria;
nose bleed;
exacerbation of colitis, hemorrhoids, irritation of the rectal mucosa, tenesmus for suppositories;
burning, dry skin, exacerbation of psoriasis.

Overdose

If the dose of the drug is exceeded, an overdose is possible, which is manifested by negative symptoms in the form of nausea, vomiting, dizziness, headache, disorientation, memory impairment. Particularly severe cases of the use of a large number of tablets ended in convulsions, numbness of the limbs, paresthesias. According to the instructions, symptomatic treatment is carried out.

Contraindications

When prescribing Indomethacin, it is necessary to pay attention to a number of contraindications in the instructions. Tablets should not be prescribed for the following conditions:

hypersensitivity to the elements of the drug;
Crohn's disease;
pregnancy;
breast-feeding;
liver pathology;
ulcerative colitis;
ulcers of the gastrointestinal tract;
liver failure;
bronchial asthma;
hyperkalemia;
epilepsy;
congenital heart defects;
urticaria or acute rhinitis provoked by the use of non-steroidal anti-inflammatory drugs;
blood clotting disorders;
hematopoietic diseases (leukopenia and anemia);
bleeding;
recent coronary artery bypass grafting;
age up to 14 years.

Indomethacin suppositories of any dosage are contraindicated for rectal bleeding, hemorrhoids, symptoms of proctitis. With caution, the drug is prescribed in the presence of conditions:

coronary artery disease;
cerebrovascular disorders;
chronic form of heart failure;
dyslipidemia;
depression;
mental disorders;
depression;
hyperlipidemia;
diabetes;
hypertension;
nicotine addiction;
cirrhosis of the liver with portal hypertension;
parkinsonism;
alcoholism;
long-term use of non-steroidal anti-inflammatory drugs;
detection of Helicobacter pylori;
thrombocytopenia;
hyperbilirubinemia;
peptic ulcer of the gastrointestinal tract;
pathology of peripheral arteries;
simultaneous use of anticoagulants, antiaggregants, oral glucocorticoids, selective serotonin reuptake inhibitors;
elderly age.

Ointment and gel are contraindicated for use in case of hypersensitivity, skin lesions in the area of application of the drug, third trimester of pregnancy, children under one year old. With caution, external use is allowed under the following conditions:

ulcer of the gastrointestinal tract in the acute phase;
breast-feeding;
bronchial asthma in combination with intolerance to non-steroidal anti-inflammatory drugs or nasal sinus polyposis;
first and second trimester of pregnancy;
children under 6 years old.

Terms of sale and storage

Candles and tablets Indomethacin are prescription drugs, gel and ointment are dispensed without a prescription from a doctor. Medicines are stored at temperatures up to 25 degrees for 3-5 years.

You can find an analogue of Indomethacin among the drugs of the non-steroidal anti-inflammatory group. These include:

Diclofenac - gel, ointment, injections, suppositories, tablets based on the component of the same name;
Aertal - powder, tablets, ointment containing aceclofenac;
Diclonac - a solution based on diclofenac sodium;
Ortofen - gel, injections, ointment containing diclofenac;
Ketorol - tablets, solution, gel based on ketorolac;
Ketanov - injection solution, tablets containing ketorolac;
Piroxicam - capsules, gel, tablets based on the substance of the same name;
Ibuprofen - suppositories, tablets, ointment, gel containing ibuprofen.

Price of Indomethacin

The drug is sold in pharmacies at prices that depend on the pricing policy, the form of release, and the volume of the pack. In Moscow, the cost will be.

Indomethacin is an active non-steroidal anti-inflammatory agent. A very powerful inhibitor that affects the synthesis of biologically active substances that are produced in the body.

Indomethacin has a pronounced analgesic effect, less - anti-inflammatory, decongestant and antipyretic.

The drug is able to significantly reduce pain, erythema, swelling, swelling of the joints, and also dull the morning stiffness of movements.

Forms of drug release - in tablets, in ointments, gels, in suppositories, in intramuscular injections.

Indomethacin tablets

Indomethacin tablets are an active anti-inflammatory drug that is very effective in treating the following diseases:

rheumatoid arthritis - an infectious-allergic disease, which is characterized by a progressive inflammatory process in the joints,
periarthritis - inflammation of the tissues that surround the joint,
osteoarthritis - diseases of the joints,
gout,
thrombophlebitis - inflammation of the wall of the veins with their subsequent blockage.

It has a therapeutic anti-inflammatory effect in:

pain in the spine, neuralgia (pain that spreads in the direction of the nerve),
myalgia (pain in the muscles),
traumatic inflammation of soft tissues (tendons, muscles, ligaments, joints) as a result of dislocations and excessive physical activity,
disease ankylosing spondylitis - diseases of the spine,
rheumatism,
degenerative and inflammatory diseases such as rheumatoid arthritis, humeroscapular periarthritis, arthrosis deformans,
diffuse connective tissue diseases,
painful menstruation,
adnexitis - inflammation of the uterine appendages,
prostatitis - inflammation of the prostate,
cystitis - inflammation of the bladder.

Instructions for use

Use the drug indomethacin after eating 1 piece three times a day, then, if necessary, this dose is increased at the rate of 8 tablets per day.

The drug is prescribed for a long time, stopping the intake before the period set by the doctor can resume painful phenomena and all treatment will be in vain.
When the therapeutic effect is achieved, indomethacin is used for another 2-3 weeks to consolidate the action.

Contraindications

Despite the effective positive effect, indomethacin is not indicated for all patients.

There are restrictions in the following cases:

with ulcerative and erosive processes,
with bronchial asthma,
period of pregnancy and lactation,
sensitivity to drug constituents,
with the so-called "aspirin triad",
in the presence of a violation of hematopoiesis,
chronic dysfunction of organs such as the kidneys and liver (inflammatory processes),
with pancreatitis,
during the second half of pregnancy,
age up to 6 years,
driving vehicles.

Side effects of indomethacin tablets

When using the drug in question, the following side effects may occur:

From the side of the nervous system. Dizziness, intense headache, fatigue, constant tinnitus, conjunctivitis.
From the side of the hematopoietic system and the heart. Gradual development of chronic heart failure, edematous syndrome, bleeding, leukopenia, anemia, agranulocytosis.
From the gastrointestinal tract. Vomiting, nausea, aching pain in the abdomen, a significant decrease in appetite, the appearance of heartburn, diarrhea, with prolonged use - an ulcer.
From the reproductive and urinary systems. Hematuria, papillary necrosis, impaired renal function.
Allergy. Rash, itching, rashes, dermatitis.

Indomethacin suppositories

Candles indomethacin in their action, indications, contraindications and side effects are similar to the tablet analogue, the difference is only in the method of administration and possible side effects.

So, candles are injected directly into the rectum. It is recommended to empty the intestines before use. Having freed the suppository from the contour packaging, it is inserted into the anus with a sharp end as deep as possible.

Apply suppositories 1 piece 1 time per day, more often at night.

The absorption of indomethacin in suppositories is somewhat faster than tablets, respectively - and the therapeutic effect is much more effective. With direct introduction into the large intestine, its effective use reaches about 90%.

Candles of indomethacin in gynecology

With gynecological diseases that have overtaken a woman, she is prescribed a handful of medicines, but the most effective are medicines in candles.

The use of such suppositories is very convenient: they begin to act immediately at the site of localization of inflammation and pain. Indomethacin suppositories are widely used in such cases.

Gynecologists prescribe these suppositories in the following cases:

with adhesions in the pelvis,
with endometriosis,
patients with uterine fibroids,
with adnexitis,
with obstruction of the uterine tubes, inflammatory gynecological diseases.

Candles with indomethacin in a short time stop (relieve) the pain syndrome.

Contraindications to the use of candles:

Patients with gynecological diseases are prescribed suppositories, excluding contraindications:

impaired integrity of the rectum,
blood clotting disorder,
cracks in the anus,
pregnancy, breastfeeding period,
haemorrhoids.

Candles indomethacin - a very cheap pleasure. In addition, it is a very effective remedy for the treatment of the diseases described above, so most often doctors prescribe candles. Reviews on the use of the considered therapeutic agent are registered only positive.

For treatment, candles are used at the rate of no more than 4 per day.
For prevention and maintenance therapy - 1 suppository at night.
You can’t even prescribe yourself such a harmless medicine on your own, let the doctor do it.

Ointment indomethacin

Indomethacin ointment is used for local anesthesia, applied to intact skin, while avoiding contact with the eyes or mucous membranes.

Apply the ointment externally, about 15 cm per day. The squeezed ointment is applied in a thin layer to the painful area. Duration of application - no more than 2.5 weeks.

Side effect

When applying the ointment, the following undesirable effects are possible:

the occurrence of dryness of the skin at the site of rubbing,
an allergic reaction to a drug
skin burning,
exacerbation of psoriasis,
rarely - asthma attacks.

Instructions for use

The drug is prescribed with great care to the elderly, also at risk for patients with the following diseases:

liver, gastrointestinal tract in history, kidneys,
dyspeptic symptoms when consumed,
arterial hypertension,
epileptic seizures,
Parkinson's disease,
heart failure.

During the course of admission, it is extremely necessary to systematically monitor the function of the kidneys and liver, as well as to monitor the peripheral blood picture. Doctors do not recommend taking indomethacin together with acetylsalicylic acid.

Do not use the drug in question simultaneously with diflunisal. With the parallel use of indomethacin with lithium preparations, there is a risk of manifestation of the toxic effects of lithium.

If indomethacin ointment is used, avoid applying the drug to the surface of wounds, to the eyes.

At the time of treatment with this remedy, it is necessary, if possible, to refrain from activities that require a fairly high concentration of attention and speed of reactions. This includes driving vehicles, working on computer machines, etc.

The pharmaceutical industry produces a limited amount of indomethacin marked "retard", which means a prolonged (long-term) effect of the drug. Such tablets are drunk 1 time per day at any time convenient for taking, candles are also placed 1 time per day (often at night).

Price ranges

The drug indomethacin belongs to economy-class drugs, so anyone in need can afford to buy it. Prices for this medicine in all neighboring countries are approximately the same.

In Russia:

tablets Indomethacin, 30 pieces - 15-18 rubles,
candles Indomethacin, 6 pieces - 41-45 rubles,
ointment Indomethacin, 40 gr - 45-50 rubles.

In Ukraine:

tablets Indomethacin, 30 pieces - 4.3 - 4.5 hryvnia,
candles Indomethacin, 6 pieces - 11.7 - 11.9 hryvnia,
ointment Indomethacin, 13.5 - 14 hryvnia.

Analogues

The pharmacological industry produces a wide range of analogues of indomethacin:

in tablets:

Metindol,
Movimed,
indocide,
indocollier,
indobene,
Indovis etc.

in ointments and gels:

Voltaren,
Diklak,
Dicloran,
Butadion and others.

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